Cybersecurity and DNA Sequencing

Researchers at the University of Florida found security risks when using portable genetic sequencers made by Oxford Nanopore Technologies--the largest provider in the product space. Oxford quickly rolled out updates to path the vulnerabilities, but devices that did not receive the updates, as well as unsecured internet systems could still leave DNA sequencers vulnerable. 

The researchers discovered three vulnerabilities, two of which could expose DNA data to copying or alteration, and one that could halt operations. Their article explains that if a specialized device is connected to a general device and/or Wi-Fi, as the portable sequencer must be for use, it is vulnerable due to potentially weak security in the the systems outside of the sequencer--even when the sequencer is up-to-date. The U.S. National Institute of Standards and Technology has recently started to consider research cases as a distinct class outside of clinical use however clear standards have not yet been provided.

Cybersecurity is a growing problem for all of us. InnovATEBIO has a Course in a Box titled "Best practices in cybersecurity", created by Victoria Ferrell at Forsyth Technical Community College that could help your students learn more about this important challenge.

Bottom line? Make sure all the devices and networks you interact with are as secure as possible, stay on guard for cyber attacks, and educate yourself about this important part of technology use.

Information Credit: Eric Hamilton, University of Florida. November 12, 2025 Security flaws in portable genetic sequencers risk leaking private DNA data.

Citation: Stillman, C., Bravo, J.E., Boucher, C. et al. Toward security-aware portable sequencing. Nat Commun 16, 9829 (2025). https://doi.org/10.1038/s41467-025-66024-z