Presenters : Sandra Porter, PhD, Digital World Biology, Bio-Link National Center, Austin Community College, Shoreline Community College and Todd Smith, PhD, Digital World Biology The wide application of DNA sequencing has made it possible to identify numerous missense mutations. Unfortunately, the act of translating the potential impact of these mutations to practical advice requires either an in-depth understanding of biochemistry and molecular interactions or access to a knowledgebase containing this kind of information. If we can teach students how to predict the effects of mutations, we could have students participate in annotating molecular structures and build that knowledgebase for clinicians, ... Read more
Presenter : Ellyn Daugherty, Rock Star Science Participants learn strategies to plan and implement innovative STEM biotech curriculum for all students at all levels, leading students to do science in adult environments. Participants will conduct 2 computer activities (molecular modeling and primer design) from the new edition of Biotechnology: Science for the New Millennium, 2017. Read more
Presenter : Sandra Porter, PhD, Digital World Biology LLC , and Bio-Link
This will be a hands on workshop where participants will have the opportunity to use bioinformatics tools to look for and evaluate drugs to treat Zika virus. We will use BLAST, multiple alignments, and molecular modeling to identify potential drugs and determine if they might work. The example below shows Sofosbuvir bound to the RNA polymerase from Hepatitis C virus.
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Presenters : Thomas Tubon, PhD, Madison College, Sandra Porter, PhD, Digital World Biology and Bio-Link
Together CRISPR and Cas provide bacteria with an adaptive immune system that allows them to identify and defend against new viral invaders. While characterizing the basic biology of this system, researchers discovered that the Cas9 protein could be harnessed to engineer genomic DNA. In this session, we will discuss the basic biology of the CRISPR / Cas system and discuss how researchers are using this system in new ways to engineer living things.
We also explored molecular models of Cas proteins ... Read more
Presenter : Sandra Porter
Preparation :
Get Cn3D
Schedule :
Part I. Get Cn3D going
A. Download 1NAJ.cn3
Turn structures
Move structures without turning
Make structures bigger / smaller
Change rendering style
Change coloring style
Show and hide parts of a structure
Make color key
B. Become familiar with Cytochrome Oxidase C
Look at chains - how many?
try different coloring styles - what do you see?
Look at active site
rendering style tubes, coloring ... Read more
